Molecular interactions within the IL-6/IL-12 cytokine/receptor superfamily
نویسندگان
چکیده
منابع مشابه
Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex.
IL-12 is a heterodimeric cytokine, composed of a p40 and a p35 subunit, that exerts its biological effects by binding to specific cell surface receptors. Two IL-12R proteins, designated human IL-12 (huIL-12) receptor beta1 (huIL-12Rbeta1) and huIL-12Rbeta2, have been previously identified. These IL-12R individually bind huIL-12 with low affinity and in combination bind huIL-12 with high affinit...
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Combination immune checkpoint blockade has demonstrated significant clinical responses in cancers infiltrated by T cells. Many tumors contain high proportions of myeloid cells and these can secrete immunosuppressive cytokines like IL-23. Our data suggest the clinical potential of using anti-CD40 (push) and anti-IL-23 mAbs (pull) to tip the IL-12/23 balance in established tumors and act as an al...
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ژورنال
عنوان ژورنال: Immunologic Research
سال: 2011
ISSN: 0257-277X,1559-0755
DOI: 10.1007/s12026-011-8209-y